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Familial-Environmental Risk Factors in South African Children With Attention-Deficit Hyperactivity Disorder (ADHD): A
Leana van Dyk1, Priscilla Springer1, Martin Kidd2
1Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
Insights
Familial and environmental factors significantly impact attention-deficit hyperactivity disorder (ADHD) in South African children. Specific risk factors and protective elements were identified, aiding potential clinical diagnosis.
Area of Science:
- Child Psychology
- Neurodevelopmental Disorders
- Epidemiology
Background:
- Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder.
- Understanding familial and environmental influences is crucial for ADHD diagnosis and management.
Purpose of the Study:
- To investigate familial and environmental risk factors associated with ADHD in South African children.
- To identify protective factors and develop a predictive model for ADHD diagnosis.
Main Methods:
- Prospective, hospital-based case-control study.
- Involved 50 children diagnosed with ADHD and 50 matched non-ADHD controls.
- Systematic assessment of familial and environmental risk factors.
Main Results:
- Significant risk factors identified: birth complications, parental psychiatric disorder, maternal ADHD, early childhood trauma, nonmaternal childcare.
- Prolonged breastfeeding demonstrated a protective effect.
- A 5-criterion model (birth complications, breastfeeding <3 months, parental tertiary education, parental psychiatric disorder, nonmaternal caregiver) achieved 74% sensitivity and 86% specificity.
Conclusions:
- Familial and environmental factors are significantly correlated with ADHD in the studied cohort.
- The developed 5-criterion model may provide valuable clinical guidance for ADHD diagnosis.
Abstract:
We investigated familial and environmental risk factors in a cohort of South African children diagnosed with attention-deficit hyperactivity disorder (ADHD). A prospective, hospital-based case control study was conducted comprising 50 children diagnosed with ADHD and 50 matched non-ADHD controls. The adjusted effect of familial-environmental risk factors on ADHD was determined by systematic assessment. Birth complications, parental psychiatric disorder, maternal ADHD, early childhood trauma, and nonmaternal child care were significant risk factors for ADHD. Prolonged breastfeeding was found to be protective. In a multivariable logistic regression model, 5 criteria (birth complications, breastfeeding <3 months, at least 1 parent with tertiary education, presence of parental psychiatric disorder, and nonmaternal primary caregiver) differentiated ADHD from non-ADHD controls with a sensitivity and specificity of 74% and 86%, respectively. We found a correlation between certain familial and environmental risk factors and ADHD. A 5-criterion multivariable logistic regression model may offer clinical guidance in ADHD diagnosis.
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