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Cardiovascular disease-related hospital admissions of patients with inflammatory arthritis
Jennie Ursum1, Mark M J Nielen2, Jos W R Twisk2
1From the Netherlands Institute for Health Services Research (NIVEL), Utrecht; the EMGO+ Institute for Health and Care Research, VU University; Department of Epidemiology and Biostatistics, Department of Internal Medicine, Department of General Practice and Elderly Care Medicine/EMGO Institute for Health and Care Research, and the Department of Rheumatology, VU University Medical Centre, Amsterdam, the Netherlands.J. Ursum, PhD; M.M.J. Nielen, PhD; J.C. Korevaar, PhD, NIVEL; J.W.R. Twisk, PhD, EMGO+ Institute for Health and Care Research, VU University, and the Department of Epidemiology and Biostatistics, VU University Medical Centre; M.J.L. Peters, PhD, Department of Internal Medicine, VU University Medical Centre; F.G. Schellevis, Professor, NIVEL, and the Department of General Practice and Elderly Care Medicine/EMGO Institute for Health and Care Research, VU University Medical Centre; M.T. Nurmohamed, PhD, Department of Internal Medicine, and the Department of Rheumatology, VU University Medical Centre. j.ursum@nivel.nl.
Insights
Patients with inflammatory arthritis (IA) face a higher risk of cardiovascular disease (CVD) hospitalizations. This study confirms increased CVD burden in IA patients, highlighting the need for proactive cardiovascular risk management.
Area of Science:
- Rheumatology
- Cardiology
- Public Health
Background:
- Patients with inflammatory arthritis (IA) have a known increased risk of cardiovascular diseases (CVD).
- Data on CVD-related hospitalizations in IA patients are limited.
- This study investigates CVD hospital admissions in a primary care population with IA.
Purpose of the Study:
- To determine the rate of cardiovascular disease (CVD)-related hospital admissions in patients with inflammatory arthritis (IA).
- To compare CVD hospitalization rates between IA patients and matched controls in a primary care setting.
Main Methods:
- Utilized electronic medical records from the Netherlands Institute for Health Services Research Primary Care database (2001-2010).
- Included newly diagnosed IA patients and matched controls (2:1 ratio).
- Retrieved hospital admission data from Dutch Hospital Data.
Main Results:
- 2615 IA patients and 5555 controls were analyzed.
- IA patients had significantly higher CVD-related hospital admissions (48% vs. 36%, p < 0.001) over 4 years.
- Increased hospitalization for ischemic heart disease (OR 1.7) and cerebrovascular disease day-care admissions (OR 2.2) observed in IA patients.
Conclusions:
- Elevated hospital admission rates confirm a greater CVD burden in patients with IA.
- These findings emphasize the critical need for enhanced cardiovascular risk management strategies in IA patients.
Objective:
Patients with inflammatory arthritis (IA) have an increased risk of cardiovascular diseases (CVD), suggesting a high rate of CVD-related hospitalizations, but data on this topic are limited. Our study addressed hospital admissions for CVD in a primary care-based population of patients with IA and controls.
Methods:
All newly diagnosed patients with IA between 2001 and 2010 were selected from electronic medical records of the Netherlands Institute for Health Services Research Primary Care database, representing a national network of general practices. Two control patients matched for age, sex, and practice were selected for each patient with IA. Hospital admission data for all patients was retrieved from the Dutch Hospital Data.
Results:
There were 2615 patients with IA and 5555 controls included in our study. CVD-related hospital admissions were observed more frequently among patients with IA as compared with control patients: 48% versus 36% (p < 0.001) in a followup period of 4 years. Patients with IA were more often hospitalized because of ischemic heart disease (OR 1.7, 95% CI 1.2-2.2) and for day-care admission because of cerebrovascular disease (OR 2.2, 95% CI 1.0-4.9).
Conclusion:
Increased hospital admission rates confirm the higher CVD burden among patients with IA compared with controls, and underscore the need for proper CVD risk management in patients with IA.
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