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Blood biomarkers and functional disability among extremely longevous individuals: a population-based study
Zuyun Liu1, Yong Wang2, Jiapin Huang1
1Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Summary
In extremely longevous women, serum albumin, lymphocyte, and neutrophil counts are linked to physical disability. These blood biomarkers show significant associations, warranting further investigation in aging populations.
Area of Science:
- Gerontology
- Biomarkers
- Functional Disability
Background:
- Functional disability is a significant health concern in aging populations.
- Limited data exist on the association between blood biomarkers and functional disability in extremely longevous individuals (95+).
Purpose of the Study:
- To investigate the association between specific blood biomarkers and functional disability in an extremely longevous population.
- To identify potential predictive markers for maintaining independence in activities of daily living among the oldest old.
Main Methods:
- Utilized data from 420 participants in the Rugao longevity cohort (China).
- Assessed functional disability using the Katz Index of Independence in Activities of Daily Living (ADL).
- Correlated serum albumin, lymphocyte count, and other biomarkers with ADL performance.
Main Results:
- In longevous women, decreased serum albumin and lymphocyte counts correlated with increased functional disability.
- Serum albumin, lymphocyte count, and neutrophil count showed significant independent associations with ADL in women after multivariate regression analysis.
- No significant associations were observed between these biomarkers and functional disability in men.
Conclusions:
- Significant associations exist between serum albumin, lymphocyte count, neutrophil count, and physical disability in extremely longevous women.
- These findings suggest potential biomarkers for monitoring or intervening in functional decline in advanced age.
- Further longitudinal studies are recommended to confirm these relationships and inform potential interventions.
