Related Experiment Video
Updated: Apr 19, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
Published on: October 24, 2018
Epigenetic effect of chronic stress on dopamine signaling and depression
Sofia Moriam1, Mahbub E Sobhani1
1Biotechnology and Genetic Engineering Discipline, Khulna University.
Abstract:
Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding effect of stress in depression. Dopamine is a key neurotransmitter important in many physiological functions, including motor control, mood, and the reward pathway. These factors lead many drugs to target Dopamine receptors in treating depressive disorders. In this review, we try to portray how chronic stress as an epigenetic factor changes the gene regulation pattern by interrupting Dopamine signaling mechanism.
Related Concept Videos
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Psychoneuroimmunology: Diabetes and Cancer
Hypothalamic-Pituitary Axis
Psychological Responses to Stress
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...

