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Related Concept Videos

Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

614
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
614

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Related Experiment Video

Updated: Apr 19, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
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Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

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Present and future perspectives on total artificial hearts.

Gino Gerosa1, Silvia Scuri1, Laura Iop1

  • 11 Division of Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy ; 2 Padua Heart Project, Division of Cardiac Surgery, A.O. of Padua, Padua, Italy ; 3 Cardiovascular Regenerative Medicine Lab, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy ; 4 Department of Cardiothoracic Surgery, Mount Sinai Hospital, New York, USA.

Annals of Cardiothoracic Surgery
|December 17, 2014
PubMed
Summary
This summary is machine-generated.

Total artificial hearts (TAHs) offer vital mechanical circulatory support (MCS) for heart failure patients awaiting transplants. Advanced TAH technology aims to improve biocompatibility and reduce complications, enhancing patient outcomes.

Keywords:
Mechanical circulatory support (MCS)heart failuretotal artificial heart (TAH)

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Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Transplantation Medicine

Background:

  • Donor organ shortages create critical risks for advanced heart failure patients awaiting transplantation.
  • Mechanical circulatory support (MCS), including ventricular assist devices (VADs), provides essential support.
  • Total artificial hearts (TAHs) are used for biventricular support as a bridge to transplant or destination therapy.

Purpose of the Study:

  • To review the history, development, and clinical applications of total artificial hearts (TAHs).
  • To discuss current technological limitations and advancements in TAH design and materials.
  • To explore future outlooks for TAHs in managing end-stage heart failure.

Main Methods:

  • Literature review of historical and current TAH technology.
  • Analysis of clinical outcomes and complications associated with existing TAHs.
  • Discussion of emerging technologies for TAH improvement.

Main Results:

  • Current TAHs, primarily positive displacement pumps, face limitations in size and associated complications.
  • Technological advancements focus on smaller, more effective TAHs with improved biocompatibility to reduce hemorrhagic and thromboembolic events.
  • Novel power systems aim to minimize infection risks by maintaining skin barrier integrity.

Conclusions:

  • TAHs are crucial for patients needing biventricular support, but current devices have limitations.
  • Future TAH development prioritizes enhanced biocompatibility, reduced complications, and infection prevention.
  • Continued innovation in TAH technology holds promise for broader clinical application and improved patient survival.