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Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

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Targeting chromatin to improve radiation response.

M M Olcina¹, S O'Dell, E M Hammond

¹CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.

The British Journal of Radiology

|December 17, 2014

Summary

This summary is machine-generated.

This review summarizes how chromatin modifications and modifiers impact DNA damage response and radiation therapy efficacy. Targeting these processes with inhibitors could enhance cancer treatment outcomes.

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

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Published on: September 20, 2018

Area of Science:

Molecular Biology
Cancer Research
Genetics

Background:

Chromatin structure, DNA wrapped around histones, influences DNA processes.
Chromatin modifications and remodellers are crucial for DNA damage sensing and repair.
Radiotherapy is a key cancer treatment, but its efficacy can be improved.

Purpose of the Study:

To review chromatin modifications and modifiers involved in the DNA damage response.
To highlight pharmacologically targetable processes with available inhibitors.
To explore the rationale for combining these inhibitors with radiation therapy.

Main Methods:

Literature review of chromatin dynamics in DNA damage response.
Analysis of pharmacological inhibitors targeting chromatin modifiers.
Synthesis of evidence supporting combination therapy with radiation.

Main Results:

Chromatin dynamics play a significant role in the early and late stages of DNA damage response.
Several chromatin modifiers are druggable targets with existing inhibitors.
Modulating chromatin could sensitize tumors to radiation therapy.

Conclusions:

Chromatin modifications and modifiers are critical regulators of DNA damage response.
Pharmacological targeting of these elements offers a promising strategy to enhance radiotherapy efficacy.
Combination therapies involving chromatin inhibitors and radiation warrant further investigation.