[The role of the substrate structure in the function of Na,K-ATPase]

A A Boldyrev, O D Lopina, I A Svinukhova

|June 1, 1989

Abstract:

The mechanism of Na,K-ATPase function is reviewed. The peculiarities of hydrolysis of various substrates are described. The experimental results testify to the effect of substrate structure on the E2----E1 transition, rate of Na+ transport, K-dependent phosphatase activation and the quaternary structure of Na,K-ATPase. A conclusion is drawn that the proton-acceptor properties of the substrate play a role in the regulation of ion transport by Na,K-ATPase.

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Abstract:

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