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Seasonal rhythm of platelet 3H-imipramine binding in normal controls
E M DeMet1, A Chicz-DeMet, J Fleischmann
1Department of Psychiatry and Human Behavior, University of California, Irvine 92717.
Biological Psychiatry
|September 1, 1989
Abstract:
The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuated about a yearly mean of 2647.5 fmol/mg. The present results underscore the importance of including seasonally matched controls in the evaluation of potential patient differences in platelet binding.