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Updated: Apr 19, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
Co-expression of CD40/CD40L on XG1 multiple myeloma cells promotes IL-6 autocrine function
Chunjian Qi1, Shengwang Tian, Jiangfang Wang
1Oncology Institute, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital, Changzhou, China,1.
Abstract:
Multiple myeloma (MM) is characterized by uncontrolled proliferation of malignant plasma cells in the bone marrow and peripheral blood. Here, we found that CD40 and CD40L co-expressed on XG1 MM cells and the coordinated expression of CD40-CD40L was critical for production and autocrine IL-6 in XG1 cells. Furthermore, TNF-α enhanced the expression of both CD40 and CD40L expression on XG1 cells. We also found that persistent CD40L/CD40 signaling was required for the constitutive activation of NF-κB in the cells.
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