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A mild copper-catalyzed aerobic oxidative thiocyanation of arylboronic acids with TMSNCS
Nan Sun1, Liusheng Che, Weimin Mo
1College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Abstract:
A facile and efficient transformation of arylboronic acids to their corresponding aryl thiocyanates has been successfully developed. Based on the CuCl-catalyzed oxidative cross-coupling reaction between arylboronic acids and trimethylsilylisothiocyanate (TMSNCS) under oxygen atmosphere, the transformation can be readily conducted at ambient temperature. The newly-developed protocol provided a competitive synthetic approach to aryl thiocyanates that can tolerate a broad range of reactive functional groups and/or strong electron-withdrawing groups.
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