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Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676)

Yoshikazu Uto1

  • 1Daiichi Sankyo Co., Ltd., Venture Science Laboratories , 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710 , Japan +813 3492 3131 ; +813 5436 8563 ; uto.yoshikazu.pw@daiichisankyo.co.jp.

Expert Opinion on Therapeutic Patents
|December 18, 2014
PubMed

Keywords:
Alzheimer’s diseaseCYP46A1cholesterol 24-hydroxylaseimidazopyridine

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Cytochrome P450 (CYP450) enzymes are a superfamily of heme-containing monooxygenases that play a pivotal role in Phase I drug metabolism by catalyzing oxidation and reduction reactions.These enzymes transform lipophilic xenobiotics into more hydrophilic metabolites, facilitating subsequent Phase II conjugation and eventual excretion. The CYP450 family is classified into families (e.g., CYP1–CYP3) and subfamilies (e.g., CYP2A, CYP2C), based on amino acid sequence homology.CYP450...
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