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Published on: December 13, 2017
Bilateral thalamic stimulation induces insomnia in patients treated for intractable tremor
Agathe Bridoux1,2, Xavier Drouot3,4, Aude Sangare1,2
1AP-HP, Groupe Henri Mondor - Albert Chenevier, Service de Physiologie Créteil, 94010, France.
Study Objectives:
To explore the influence of acute bilateral ventral intermediate thalamic nucleus (VIM) stimulation on sleep.
Design:
Three consecutive full-night polysomnography recordings were made in the laboratory. After the habituation night, a random order for night ON-stim and OFF-stim was applied for the second and third nights.
Setting:
Sleep disorders unit of a university hospital.
Patients:
Eleven patients with bilateral stimulation of the ventral intermediate nucleus of the thalamus (VIM) for drug-resistant tremor.
Measurements:
Sleep measures on polysomnography.
Results:
Total sleep time was reduced during night ON-stim compared to OFF- stim, as well as rapid eye movement sleep percentage while the percentage of N2 increased. Wakefulness after sleep onset time was increased.
Conclusion:
Our results show that bilateral stimulation of the VIM nuclei reduces sleep and could be associated with insomnia.
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