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Cylindroma: an update.

Clarice Jordão¹, Taissa Canedo de Magalhães, Tullia Cuzzi

¹Sectors of Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

International Journal of Dermatology

|December 18, 2014

Summary

This summary is machine-generated.

This review covers cylindroma, a rare skin adnexal tumor. While often benign and more common in women, malignant forms can arise, particularly in Brooke-Spiegler syndrome, with a known genetic link.

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Area of Science:

Dermatology
Oncology
Genetics

Background:

Cylindroma is a rare neoplasm originating from cutaneous adnexal structures, predominantly affecting the scalp and face.
Both benign and malignant forms exist, with benign cylindromas being more common in women and presenting as solitary or multiple autosomal variants.
Malignant transformation is a concern, especially in multiple variants and in the context of Brooke-Spiegler syndrome.

Purpose of the Study:

To review the current literature on cylindroma.
To summarize key aspects of cylindroma, including epidemiology, clinical presentation, and histopathological considerations.
To highlight the genetic basis and malignant potential of cylindromas, particularly in Brooke-Spiegler syndrome.

Main Methods:

Literature review of recent studies on cylindroma.
Synthesis of information regarding tumor origin, classification, and clinical behavior.
Analysis of histopathological findings and genetic associations.

Main Results:

Benign cylindromas are more prevalent in females, with both solitary and multiple autosomal forms.
Malignant cylindromas are associated with Brooke-Spiegler syndrome.
Malignant transformation occurs more frequently in multiple cylindroma variants compared to solitary tumors.

Conclusions:

The histopathological basis and precise origin of cylindromas remain subjects of ongoing research and debate.
A genetic predisposition is established for cylindromas occurring within the Brooke-Spiegler syndrome.
Understanding the factors influencing malignant transformation is crucial for patient management.