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Updated: Apr 19, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
Published on: August 5, 2022
Systematic evaluation of cancer risk associated with DNMT3B polymorphisms
Fujiao Duan1, Shuli Cui, Chunhua Song
1Department of Hospital Infection Management, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, China, fjduan@yeah.net.
DNA methyltransferase 3B (DNMT3B) gene variations may decrease cancer risk, particularly in Asian populations and for colorectal cancer. Further research is needed to confirm these protective associations.
Area of Science:
- Genetics and Genomics
- Cancer Epidemiology
- Molecular Biology
Background:
- Genetic variations in DNA methyltransferase 3B (DNMT3B) play a role in epigenetic regulation.
- Understanding the association between DNMT3B polymorphisms and cancer risk is crucial for personalized medicine.
Purpose of the Study:
- To quantify the association between specific DNMT3B gene variations (rs2424913, rs1569686, rs6087990, rs2424908) and cancer risk.
- To evaluate the potential protective or risk-modifying effects of these polymorphisms across different populations.
Main Methods:
- Systematic literature review of case-control studies.
- Methodological quality assessment using the Newcastle-Ottawa Scale.
- Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of associations.
Main Results:
- Analysis of 34 studies revealed significant associations for several DNMT3B polymorphisms.
- rs2424913 showed a negative association with cancer risk in Africans.
- rs1569686, rs6087990, and rs2424908 polymorphisms were associated with decreased cancer risk, particularly in the Asian population and for colorectal cancer.
Conclusions:
- DNMT3B polymorphisms, especially rs1569686, rs6087990, and rs2424908, may confer a reduced risk of cancer.
- The protective effect appears more pronounced in Asian populations and for colorectal cancer.
- Multicenter studies are recommended to validate these findings and further elucidate the role of DNMT3B in cancer development.
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