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Updated: Apr 19, 2026
09:32
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
Published on: April 11, 2018
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Biomechanical aspects of the muscle-bone interaction
Keith G Avin1, Susan A Bloomfield, Ted S Gross
1Center for Translational Musculoskeletal Research and Department of Physical Therapy, School of the Health and Rehabilitation Sciences, Indiana University, 1140 W. Michigan St., CF-120, Indianapolis, IN, USA, keigavin@iu.edu.
Current Osteoporosis Reports
|December 18, 2014
Summary
Muscle forces mechanically stimulate bone, influencing its adaptation and homeostasis. This review explores muscle-generated mechanical stimuli and their impact on bone biology.
Area of Science:
- Biomechanics
- Skeletal Physiology
- Musculoskeletal Interactions
Background:
- Growing interest in skeletal muscle and bone interactions at genetic and molecular levels.
- Mechanical coupling is essential for muscle-bone genetic and molecular linkages.
- Muscle attachment to bone and functional activity create mechanical stimuli.
Purpose of the Study:
- To explore the mechanical relationship between muscle and bone.
- To investigate stimuli muscle imparts upon bone.
- To review models and data on muscle-bone mechanical interactions.
Main Methods:
- Focus on the mechanical relationship between muscle and bone.
- Exploration of stimuli generated by muscle.
- Review of models used to study this relationship.
Main Results:
- Muscle forces are a key mechanical stimulus for bone.
- Understanding how muscle forces modulate bone homeostasis and adaptation is crucial.
- Low-magnitude, high-frequency stimuli from muscle require further investigation.
Conclusions:
- The mechanical interplay between muscle and bone is fundamental.
- Further research is needed to fully elucidate muscle-generated stimuli on bone.
- Models are vital for advancing our understanding of these interactions.
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