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Renalase is removed by kidneys and during dialysis - excess related to CKD complications?

Jolanta Malyszko1, Ewa Koc-Zorawska, Marcin Zorawski

  • 12nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University, 15-276 Bialystok, M. Sklodowskiej-Curie 24a, Poland. jolmal@poczta.onet.pl.

Current Vascular Pharmacology
|December 18, 2014
PubMed

Insights

Kidney disease (CKD) complications like hypertension may involve renalase. This study found renalase in ultrafiltrate and urine, with levels varying by kidney function and dialysis type, suggesting a role in CKD cardiovascular risks.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) commonly leads to hypertension and cardiovascular (CV) disorders.
  • Renalase, produced by kidneys and cardiomyocytes, is implicated in CKD-related hypertension and CV complications.
  • Conflicting data exists regarding serum renalase levels in CKD patients, necessitating further investigation.

Purpose of the Study:

  • To assess serum renalase concentration in CKD patients undergoing different dialysis modalities (hemodialysis [HD] and hemodiafiltration [HDF]) and nephrectomy statuses.
  • To investigate the presence and levels of renalase in urine and ultrafiltrate of hemodialysis patients.
  • To evaluate the impact of hemodialysis sessions on renalase concentrations.

Main Methods:

  • Assessed renalase concentration in plasma, ultrafiltrate, and urine of 100 hemodialysis patients using commercial tests.
  • Included 17 hemodiafiltration patients and 24 healthy controls in the study.
  • Utilized Western Blot analysis to further assess renalase concentration.

Main Results:

  • Renalase was detected in the ultrafiltrate of hemodialysis patients, irrespective of dialyzer type.
  • Urine renalase concentration was higher in healthy controls than in hemodialysis patients.
  • Anuric patients exhibited higher renalase concentrations than those with residual diuresis; renalase correlated with urine output and was lower in HDF than HD patients.

Conclusions:

  • The kidneys eliminate renalase, and its elevated levels may contribute to cardiovascular diseases in CKD patients.
  • Findings suggest renalase plays a role in the pathophysiology of CKD and its associated cardiovascular complications.
  • Further research is warranted to elucidate the precise mechanisms linking renalase to cardiovascular risk in CKD.
Abstract

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