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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Benzo(a)pyrene disrupts mouse preimplantation embryo development.

Shaoquan Zhan¹, Xiya Zhang¹, Shanbo Cao²

¹Key Laboratory of Reproductive Medicine of Guangdong Province, First Affiliated Hospital and School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.

Fertility and Sterility

|December 18, 2014

Summary

This summary is machine-generated.

Benzo(a)pyrene (BaP) exposure significantly harms early embryo development, increasing DNA damage and cell death. This study reveals BaP

Keywords:

Benzo(a)pyrene DNA damage preimplantation embryo reactive oxygen species telomere

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Area of Science:

Reproductive toxicology
Developmental biology
Environmental health

Background:

Benzo(a)pyrene (BaP) is a common environmental pollutant.
Physiologic concentrations of BaP are found in human follicular fluid and serum.
BaP's impact on early embryonic development requires further investigation.

Purpose of the Study:

To investigate the effects of Benzo(a)pyrene (BaP) on preimplantation mouse embryo development.
To assess BaP's impact on embryo quality, DNA integrity, and cell apoptosis.
To evaluate BaP's toxic effects on the inner cell mass (ICM) using embryonic stem cells (ESCs).

Main Methods:

Mouse zygotes and ESCs were exposed to 5 nM or 50 nM BaP.
Embryo development efficiency, quality (cell number, apoptosis), and DNA damage were assessed.
ESC model used to evaluate BaP's effects on ICM pluripotent cells.

Main Results:

BaP exposure significantly increased reactive oxygen species (ROS) levels in zygotes.
Increased cell apoptosis, reduced Oct4/Nanog-positive ICM cells, and DNA damage were observed in BaP-treated blastocysts.
Mouse ESCs showed significant DNA damage after BaP exposure, indicating effects on pluripotent cells.

Conclusions:

Benzo(a)pyrene (BaP) disrupts early embryo development by impairing cell growth and genomic DNA stability.
BaP exposure increases cell apoptosis in preimplantation embryos.
BaP poses a significant risk to reproductive health and embryonic development.