Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

6.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.4K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.7K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.7K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

4.1K
4.1K
Stem Cell Culture01:17

Stem Cell Culture

6.7K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.7K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The emergence of human influence on the ozone layer by the 1960s.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Continuing industrial emissions are delaying the recovery of the stratospheric ozone layer.

Nature communications·2026
Same author

Suicidal Thoughts and Self-Harm Behavior During the COVID-19 Pandemic in the United Kingdom: A Repeated Cross-Sectional Population-Based Survey Study.

Health science reports·2026
Same author

Cosmic ray-driven electron-induced reaction theory does not quantify spatiotemporal variations in lower-stratospheric ozone and temperature.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Detectable global temperature responses to wildfires and volcanic eruptions.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Stigma and attitude towards persons with mental illness among healthcare workers in a tertiary care hospital, Pondicherry, South India: A cross-sectional study.

Indian journal of psychiatry·2025

Related Experiment Video

Updated: Apr 19, 2026

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

15.4K

Banking on iPSC--is it doable and is it worthwhile.

Susan Solomon1, Fernando Pitossi, Mahendra S Rao

  • 1New York Stem Cell Foundation, 1995 S. Broadway, New York, NY, 10023, USA.

Stem Cell Reviews and Reports
|December 18, 2014
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) offer personalized medicine potential. A moderate-sized bank of diverse iPSC lines, matched for HLA types, could enable accessible cell therapies.

More Related Videos

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
09:54

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Published on: April 18, 2019

14.7K
Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids
10:52

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids

Published on: June 5, 2015

13.7K

Related Experiment Videos

Last Updated: Apr 19, 2026

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

15.4K
Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
09:54

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Published on: April 18, 2019

14.7K
Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids
10:52

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids

Published on: June 5, 2015

13.7K

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Immunology

Background:

  • Induced pluripotent stem cells (iPSCs) and differentiation protocols have advanced disease research and personalized medicine.
  • Realizing iPSC potential requires addressing cell acquisition, regulatory compliance, and cost for widespread therapy.
  • Accessible patient-specific cell therapy hinges on effective cell collection, storage, and distribution strategies.

Purpose of the Study:

  • To propose a viable model for a stem cell bank to facilitate personalized medicine.
  • To address challenges in cell therapy accessibility, including HLA matching and cost-effectiveness.
  • To outline the construction and operational strategy for a moderate-sized iPSC bank.

Main Methods:

  • Reviewing challenges in iPSC-based therapy delivery.
  • Proposing a moderate-sized iPSC bank model with diverse HLA allele combinations.
  • Suggesting differentiated cells be made available to matched recipients based on need.
  • Discussing the development and construction of such a bank.

Main Results:

  • A moderate-sized iPSC bank with diverse HLA phenotypes can be a solution for personalized medicine.
  • Banking selected HLA types from screened healthy individuals offers a path to accessible cell therapy.
  • This approach addresses key logistical and regulatory hurdles for iPSC-based treatments.

Conclusions:

  • A strategically curated iPSC bank is crucial for advancing personalized medicine.
  • Matching iPSC-derived cells to recipients via HLA typing enhances therapeutic efficacy and safety.
  • This model provides a scalable and cost-effective framework for delivering iPSC-based regenerative therapies.