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Related Experiment Video

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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Anthelmintics - from discovery to resistance.

Adrian J Wolstenholme1, Richard J Martin2

  • 1Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA ; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA.

International Journal for Parasitology. Drugs and Drug Resistance
|December 18, 2014
PubMed
Summary

Researchers explored anthelmintic drug discovery, modes of action, and resistance, covering human and veterinary parasites. Efforts include novel drug discovery, repurposing, and advanced screening techniques to combat parasite resistance.

Keywords:
AnthelminticsDrug discoveryResistanceScientific meeting

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Area of Science:

  • Parasitology
  • Drug Discovery
  • Anthelmintics

Background:

  • A scientific meeting on "Anthelmintics: From Discovery to Resistance" convened in February 2014.
  • The meeting addressed key themes including drug discovery, mechanisms of action, and the growing issue of resistance.
  • Attendees represented diverse academic and industrial backgrounds, fostering interdisciplinary collaboration.

Purpose of the Study:

  • To summarize and introduce key scientific papers presented at the "Anthelmintics: From Discovery to Resistance" meeting.
  • To highlight current global efforts in anthelmintic drug discovery and development.
  • To discuss the mechanisms and management strategies for drug resistance in parasites.

Main Methods:

  • Review and synthesis of selected papers from the 2014 meeting.
  • Focus on drug discovery approaches including ion channels, protein kinases, and cysteine proteases.
  • Inclusion of novel whole-organism screening techniques and resistance management strategies.

Main Results:

  • Several papers detailed ongoing worldwide drug discovery initiatives, including drug repurposing and novel compound identification.
  • New whole-organism screening methodologies were presented, offering advanced techniques for parasite drug discovery.
  • Discussions covered critical aspects of drug resistance mechanisms and effective management in both human and veterinary contexts.

Conclusions:

  • The field of anthelmintics is actively pursuing new drug discovery avenues and innovative screening methods.
  • Addressing and managing anthelmintic resistance is a crucial component of current research and development.
  • The integration of academic and industrial expertise is vital for advancing anthelmintic therapies.