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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

90
Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
90

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Evaluation of Antioxidant and Anthelmintic Properties of Tithonia diversifolia Extracts Against Gastrointestinal Nematode Eggs Using In Vitro Assays
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Anthelmintic resistance in equine nematodes.

Jacqueline B Matthews1

  • 1Moredun Research Institute, Pentlands Science Park, Edinburgh, Midlothian, EH26 0PZ, UK.

International Journal for Parasitology. Drugs and Drug Resistance
|December 18, 2014
PubMed
Summary

Widespread anthelmintic use for horse nematodes has led to resistance. New strategies focus on targeted treatments and improved management to control parasites effectively.

Keywords:
AnthelminticsDiagnosticsEfficacy testEgg reappearance periodFaecal egg countHorseNematodesResistance

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Area of Science:

  • Equine parasitology
  • Veterinary pharmacology

Background:

  • Over 40 years of indiscriminate anthelmintic use for horse nematode control.
  • Three main anthelmintic classes registered: benzimidazoles, tetrahydropyrimidines, and macrocyclic lactones.
  • Focus on egg suppression regimens led to reduced clinical disease but increased anthelmintic resistance.

Purpose of the Study:

  • To review recent advances in equine nematode control strategies.
  • To address the growing issue of anthelmintic resistance in horse nematodes.
  • To highlight the shift towards management practices and targeted treatments.

Main Methods:

  • Review of field studies and research on anthelmintic resistance.
  • Analysis of diagnostic advancements for fecal egg counts (FEC).
  • Evaluation of optimized protocols for anthelmintic efficacy testing.

Main Results:

  • Widespread benzimidazole and pyrantel resistance in cyathostomins globally.
  • Emerging cyathostomin resistance to macrocyclic lactones.
  • Increasing concern over ivermectin resistance in Parascaris equorum.

Conclusions:

  • Anthelmintic resistance necessitates a move away from frequent, broad-spectrum treatments.
  • Integrated strategies combining improved grazing management and FEC-directed treatments are crucial.
  • Development of robust diagnostic tools and efficacy testing is vital for sustainable parasite control.