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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Sleep disordered breathing in interstitial lung disease: A review
Lauren K Troy1, Tamera J Corte1
1Lauren K Troy, Tamera J Corte, Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Sydney NSW 2050, Australia.
World Journal of Clinical Cases
|December 18, 2014
Summary
Patients with interstitial lung disease often have poor sleep quality, leading to fatigue. Sleep-disordered breathing and nocturnal oxygen desaturation are common and linked to worse outcomes.
Area of Science:
- Pulmonology
- Sleep Medicine
- Critical Care
Background:
- Interstitial lung disease (ILD) patients frequently report fatigue, often linked to poor sleep quality.
- Abnormal sleep architecture and fragmentation are common findings on polysomnography in ILD.
- Sleep-disordered breathing (SDB) is prevalent, especially in idiopathic pulmonary fibrosis (IPF).
Purpose of the Study:
- To explore the relationship between sleep disturbances and ILD.
- To investigate the prevalence and potential causes of SDB in ILD patients.
- To examine the impact of nocturnal oxygen desaturation on mortality and pulmonary hypertension in ILD.
Main Methods:
- Polysomnography to assess sleep architecture and fragmentation.
- Evaluation of sleep-disordered breathing prevalence, including obstructive sleep apnea.
- Analysis of nocturnal oxygen desaturation patterns and their correlation with clinical outcomes.
Main Results:
- Patients with ILD commonly exhibit abnormal sleep patterns and fragmentation.
- SDB, particularly obstructive sleep apnea, is prevalent in ILD, with potential contributing factors including upper airway collapsibility and ventilatory instability.
- Nocturnal oxygen desaturation is frequent in ILD, irrespective of SDB, and is associated with increased mortality and potentially pulmonary hypertension.
Conclusions:
- Poor sleep quality significantly contributes to fatigue in ILD patients.
- SDB and nocturnal oxygen desaturation are critical, under-recognized issues in ILD management.
- Sleep-related hypoxemia may play a role in the pathogenesis of pulmonary hypertension and mortality in ILD.
Keywords:
Interstitial lung diseaseNocturnal hypoxiaObstructive sleep apnoeaPulmonary fibrosisSleep disordered breathingMore Related Videos
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