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Spiroguanidine rhodamines as fluorogenic probes for lysophosphatidic acid
Lei Wang1, Martha Sibrian-Vazquez, Jorge O Escobedo
1Department of Chemistry, Portland State University, Portland, OR 97201, USA. strongin@pdx.edu.
Abstract:
Direct determination of total lysophosphatidic acid (LPA) was accomplished using newly developed spiroguanidines derived from rhodamine B as universal fluorogenic probes. Optimum conditions for the quantitative analysis of total LPA were investigated. The linear range for the determination of total LPA is up to 5 μM with a limit of detection of 0.512 μM.

