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Fentanyl transdermal patch (Durogesic® D-TRANS) for post abdominal laparotomy analgesia: a double blind randomized
H Hosseini1, S Kargar, S M Shiryazdi
1Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran - saeedkargar@yahoo.com.
Minerva Chirurgica
|December 18, 2014
Summary
The fentanyl transdermal patch (Duro-gesic® D-TRANS) effectively reduced pain after surgery. This method for post-laparotomy analgesia showed a good safety profile with manageable side effects.
Area of Science:
- Anesthesiology and Pain Management
- Pharmacology
- Surgical Recovery
Background:
- The fentanyl transdermal patch (Duro-gesic® D-TRANS) is indicated for chronic pain management.
- Postoperative pain control after laparotomy requires effective and safe analgesia.
Purpose of the Study:
- To evaluate the efficacy and safety of the fentanyl transdermal patch for post-laparotomy pain relief.
- To compare fentanyl transdermal patch analgesia with placebo in patients undergoing elective laparotomy.
Main Methods:
- A randomized controlled trial involving 120 patients undergoing elective laparotomy.
- Patients received either fentanyl transdermal patches (25 and 50 µg) or placebo preoperatively.
- Postoperative pain scores, supplementary morphine use, and adverse events were monitored for 36 hours.
Main Results:
- Fentanyl transdermal patch group showed significantly lower mean pain scores over 36 hours compared to placebo (P=0.01).
- The fentanyl group required significantly less supplementary morphine (P<0.001) with longer intervals between doses (P=0.04).
- Adverse effects like nausea, vomiting, and itching were not significantly different; however, dizziness was more frequent in the fentanyl group (P=0.02).
Conclusions:
- The fentanyl transdermal patch system is a safe and effective option for post-laparotomy analgesia.
- The observed adverse effects were generally not serious, suggesting a favorable risk-benefit profile.
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