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Smoking as risk factor for chronic kidney disease: systematic review

Ubiracé Fernando Elihimas Júnior¹, Helen Conceição dos Santos Elihimas², Victor Macedo Lemos¹

¹Universidade Federal de Pernambuco.

Jornal Brasileiro De Nefrologia

|December 18, 2014

Abstract

Introduction:

Chronic kidney disease (CKD) and smoking are public health problems.

Objective:

To assess smoking as a risk factor for progression of CKD.

Methods:

We conducted a systematic review in Medline, LILACS, SciELO, Google Scholar, Embase and Trials.gov with articles published until February/2013. Were included: cohort, clinical trials and case-control. Performed in humans, aged ≥ 18 years with smoking as a risk factor for progression of CKD. We excluded studies that reported no smoking and CKD in the title or had proposed to reduce smoking.

Results:

Among 94 citations, 12 articles were selected. Of these, six were multicenter conducted in developed countries, four were randomized. Males predominated 51-76%. There was associated with smoking progression in 11 studies. It was found that the consumption ≥ 15 packs/ year increases the risk of progression of CKD.

Conclusion:

Smoking is a risk factor for progression of CKD.

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