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Updated: Apr 19, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Tomographic imaging of fragmented cortical bone heteroimplant and methylmethacrylate in segmental bone defect of
Silvio Henrique de Freitas1, Renata Gebara Sampaio Dória2, Fábio de Souza Mendonça2
1Faculty of Veterinary Medicine, University of Cuiaba, Cuiaba, MT, Brazil.
Purpose:
To evaluate the performance of composites consisting of fragmented cortical bone heteroimplant in association with methylmethacrylate preserved in 98% glycerin, in segmental bone defect of rabbit tibia medial metaphysis.
Methods:
In this study were used twelve adult New Zealand rabbits, divided into three groups of four animals each: G30 (30 days), G60 (60 days) and G90 (90 days). The bone defects previously created in the tibia were filled with composites and both were evaluated by cone-beam computed tomography, immediately after surgery and after 30, 60, and 90 days.
Results:
The composites fulfilled and remained in the sites of bone defects in all cases and were not registered signals of infection, migration or rejection.
Conclusions:
The implanted composites promoted the bone defects repair without signals of infection and/or rejection. The composites are one more option for bone defects repair.
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