Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

Phagocytosis of Apoptotic Cells

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Diverse infection models demonstrate robust resistance of <i>Mycobacterium tuberculosis</i> to innate immunity.

bioRxiv : the preprint server for biology·2026

Same author

Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response.

Science (New York, N.Y.)·2026

Same author

Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility.

bioRxiv : the preprint server for biology·2026

Same author

<i>Shigella</i> OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils.

eLife·2025

Same author

Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ.

Cell host & microbe·2025

Same journal

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026

Same journal

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.

Immunity·2026

Same journal

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection.

Immunity·2026

Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026

Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026

Same journal

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

Immunity·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 19, 2026

Bone Marrow-derived Macrophage Production

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

The macrophage paradox.

Jordan V Price¹, Russell E Vance²

¹Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

|December 18, 2014

Summary

This summary is machine-generated.

Many pathogenic bacteria thrive inside macrophages, cells designed to destroy them. This "macrophage paradox" suggests pathogens exploit complex macrophage biology as a unique replicative niche.

More Related Videos

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Related Experiment Videos

Last Updated: Apr 19, 2026

Bone Marrow-derived Macrophage Production

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Area of Science:

Immunology
Microbiology
Cell Biology

Background:

Macrophages are crucial immune cells that engulf and eliminate microbes.
Intracellular bacterial pathogens often replicate within macrophages, despite their destructive capabilities.

Purpose of the Study:

To investigate the "macrophage paradox": why pathogens replicate within these phagocytic cells.
To explore if macrophage replication is an unavoidable pathogen trait or an exploitable niche.

Main Methods:

Review of existing literature on macrophage-pathogen interactions.
Analysis of macrophage biology and pathogen replication strategies.

Main Results:

Pathogenic bacteria's replication within macrophages is not fully explained by their inability to be destroyed.
Macrophage complexity offers unique cellular and metabolic advantages for pathogen survival and replication.

Conclusions:

The "macrophage paradox" is resolved by recognizing macrophages as a rich and complex replicative niche for pathogens.
Understanding this niche is key to comprehending intracellular bacterial pathogenesis.