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Updated: Apr 19, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
[Pleiotropic activity of 3-hydroxy-3-methyl-glutharyl-coenzyme a inhibitors (statins). therapeutic potential in
Abstract:
3-Hydroxy-3-Methyl-Glutharyl-Coenzyme A reduct- ase inhibitors, known as statins, form a group of chemical compounds that are characterized by the ability to inhibit cholesterol synthesis. Statins have proved their efficacy as potent drugs in the primary and secondary prevention of cardiovascular events. It has also been shown that the thera- peutic effects of statins go beyond reduction of cholesterol level. These properties, which are separate from the influ- ence on cholesterol synthesis, are sometimes called the pleio- tropic effect. This effect comprises immunomodulation, an anti-inflammatory effect, and endothelial function recovery.
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