Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

469
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
469
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

702
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
702
Factors Affecting Solubility04:01

Factors Affecting Solubility

39.5K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
39.5K
Solubility03:00

Solubility

23.0K
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
23.0K
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

321
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
321
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

338
Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
338

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and characterization of monoclonal antibodies to spring viraemia of carp virus.

Veterinary immunology and immunopathology·2008
Same author

Electrophysiological characterization of a novel Kv channel blocker N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl) ]bis(4-methyl)-benzenesulfonamide found in virtual screening.

Acta pharmacologica Sinica·2008
Same author

Cloning and characterization of an rRNA methyltransferase from Sorangium cellulosum.

Biochemical and biophysical research communications·2008
Same author

Reconstruction of anophthalmic orbits and contracted eye sockets with microvascular radial forearm free flaps.

Ophthalmic plastic and reconstructive surgery·2008
Same author

Using low intensity ultrasound to improve the efficiency of biological phosphorus removal.

Ultrasonics sonochemistry·2008
Same author

[Study on the spectrum of the flocculent conformation of polymer ferric sulfate flocculants].

Guang pu xue yu guang pu fen xi = Guang pu·2008

Related Experiment Video

Updated: Apr 19, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
05:08

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

17.9K

[Lead compound optimization strategy (3)--Structure modification strategies for improving water solubility].

Zeng Li, Jiang Wang, Yu Zhou

    Yao Xue Xue Bao = Acta Pharmaceutica Sinica
    |December 19, 2014
    PubMed
    Summary

    Improving water solubility of organic drugs is crucial for potency and pharmacokinetics. Structure modification strategies like salt formation and polar group introduction offer effective solutions for drug discovery challenges.

    More Related Videos

    Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
    10:33

    Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

    Published on: October 26, 2015

    11.9K
    Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
    07:20

    Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

    Published on: October 6, 2023

    4.7K

    Related Experiment Videos

    Last Updated: Apr 19, 2026

    Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
    05:08

    Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

    Published on: September 20, 2017

    17.9K
    Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
    10:33

    Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

    Published on: October 26, 2015

    11.9K
    Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
    07:20

    Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

    Published on: October 6, 2023

    4.7K

    Area of Science:

    • Medicinal Chemistry
    • Physical Chemistry
    • Drug Discovery

    Background:

    • Water solubility is a critical physicochemical property for organic small molecule drugs.
    • Good water solubility correlates with enhanced drug potency and favorable pharmacokinetic profiles.
    • Addressing poor water solubility is a significant challenge in modern drug discovery.

    Purpose of the Study:

    • To review effective structure modification strategies for enhancing drug water solubility.
    • To provide insights into optimizing solubility based on established physicochemical principles.
    • To consolidate various approaches for improving the solubility of drug candidates.

    Main Methods:

    • Literature review of structure modification techniques for water solubility enhancement.
    • Analysis of strategies including salt formation, polar group introduction, and liposolubility reduction.
    • Examination of conformation optimization and prodrug approaches.

    Main Results:

    • Salt formation effectively increases aqueous solubility through ionic interactions.
    • Introduction of polar functional groups enhances interactions with water molecules.
    • Reducing lipophilicity and optimizing molecular conformation can significantly improve solubility.
    • Prodrug strategies offer a viable route to temporarily modify solubility.

    Conclusions:

    • Structure modification is a direct and effective method to improve drug water solubility.
    • A combination of strategies may be necessary for optimal solubility enhancement.
    • These strategies are vital for advancing drug candidates through the discovery and development pipeline.