Related Experiment Video

Updated: Apr 19, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

36.2K

[Mechanism of prostate cancer invasion and metastasis]

Shinichi Sakamoto, Tomohiko Ichikawa

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 19, 2014
    PubMed

    More Related Videos

    A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting05:34

    A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting

    Published on: November 20, 2015

    34.5K
    Pre-clinical Orthotopic Murine Model of Human Prostate Cancer07:01

    Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

    Published on: August 29, 2016

    15.4K

    Related Concept Videos

    Metastasis02:30

    Metastasis

    Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
    Epithelial-to-Mesenchymal Transition
    The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
    7.0K
    Cancer Cell Migration through Invadopodia01:35

    Cancer Cell Migration through Invadopodia

    Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
    3.5K
    Cell Migration01:19

    Cell Migration

    Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
    7.6K
    Cell Migration01:09

    Cell Migration

    Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
    19.3K
    Tumor Progression02:07

    Tumor Progression

    Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
    Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
    8.0K
    Chemotaxis and Direction of Cell Migration01:21

    Chemotaxis and Direction of Cell Migration

    Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
    6.3K