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Updated: Apr 19, 2026
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
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[Antisense oligodeoxynucleotide therapy for castration-resistant prostate cancer].
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 19, 2014
Summary
Antisense oligodeoxynucleotide (AS ODN) therapy shows promise for treating advanced prostate cancer by targeting specific genes. This review summarizes AS ODN progress and clinical trial data for castration-resistant prostate cancer (CRPC).
Area of Science:
- Nucleic acid chemistry
- Molecular biology
- Oncology
Context:
- Prostate cancer (PC) progression to castration-resistance (CR) involves specific gene expression.
- Clusterin and heat shock protein 27 are key targets in CRPC.
- Antisense oligodeoxynucleotide (AS ODN) technology offers targeted gene silencing.
Purpose:
- To review the therapeutic strategy of AS ODN for castration-resistant prostate cancer (CRPC).
- To discuss current and completed clinical trial data for AS ODN in CRPC.
- To explore future prospects of AS ODN therapy for CRPC.
Summary:
- Recent advances in nucleic acid chemistry enable AS ODN technology for specific gene expression inhibition.
- AS ODN therapy is being investigated for CRPC, targeting genes like clusterin and heat shock protein 27.
- This review consolidates progress, clinical trial outcomes, and future potential of AS ODN for CRPC.
Impact:
- AS ODN therapy presents a novel strategy for treating difficult-to-treat prostate cancers.
- Clinical trial data will inform the efficacy and safety of AS ODNs in CRPC patients.
- This research paves the way for personalized gene-targeted therapies in oncology.
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