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Updated: Apr 19, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[ASC-J9 for castration-resistant prostate cancer]
Abstract:
Androgen deprivation therapy has been the standard treatment for the patients with advanced prostate cancer. Androgen deprivation therapy initially suppresses the growth of prostate cancer. However, most patients eventually progress to castration-resistant prostate cancer. Novel drugs, including enzalutamide and abiraterone acetate, are recently able to be used for the patients with castration-resistant prostate cancer. Even so, the therapeutic options for castration-resistant prostate cancer are not enough. Interestingly, androgen receptor degradation enhancer ASC-J9 is reported to degrade the androgen receptor, resulting in the suppression of the growth in castration-resistant prostate cancer cells. In this chapter, ASC-J9 for prostate cancer is reviewed.
Insights
Androgen deprivation therapy is standard for advanced prostate cancer, but resistance develops. Androgen receptor degrader ASC-J9 shows promise for treating castration-resistant prostate cancer by degrading the androgen receptor.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
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