Related Experiment Video

Updated: Apr 19, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.7K

[New inhibitors of adrenal androgen synthesis enzymes]

Atsushi Mizokami

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 19, 2014
    PubMed

    Insights

    New medicines target prostate cancer's enhanced androgen sensitivity during therapy. This summary focuses on adrenal androgen synthesis inhibitors, crucial for understanding treatments for castration-resistant prostate cancer (CRPC).

    Area of Science:

    • Oncology
    • Endocrinology
    • Pharmacology

    Background:

    • Prostate cancer (PC) androgen sensitivity increases during hormonal therapy.
    • Low-concentration dihydrotestosterone (DHT) from adrenal androgens and cytokines drives castration-resistant prostate cancer (CRPC) by activating the androgen receptor (AR).
    • Emerging therapies target these mechanisms for CRPC treatment.

    Purpose of the Study:

    • To provide fundamental knowledge on new medicines for CRPC.
    • To describe adrenal androgen synthesis inhibitors targeting the Androgen-AR axis.

    Main Methods:

    • Review of recent developments in CRPC pharmacotherapy.
    • Focus on inhibitors of adrenal androgen synthesis pathways.
    • Analysis of mechanisms targeting the Androgen-AR axis.

    Main Results:

    • New medicines targeting DHT synthesis and AR signaling are in clinical use or trials.
    • Adrenal androgen synthesis inhibitors represent a key therapeutic strategy.
    • Understanding these agents is vital for managing advanced prostate cancer.

    Conclusions:

    • Adrenal androgen synthesis inhibitors are important novel agents for CRPC.
    • Mastering the knowledge of these drugs is essential for clinicians.
    • These therapies offer new hope for patients with advanced prostate cancer.

    More Related Videos

    Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands08:37

    Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

    Published on: October 2, 2018

    25.9K
    Murine Prostate Micro-dissection and Surgical Castration08:49

    Murine Prostate Micro-dissection and Surgical Castration

    Published on: May 11, 2016

    48.3K

    Related Concept Videos

    Hormones of the Adrenal Glands01:31

    Hormones of the Adrenal Glands

    Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
    The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
    7.0K
    Adrenal Gland Disorders01:27

    Adrenal Gland Disorders

    Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
    Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
    4.2K
    Antihypertensive Drugs: Direct Renin Inhibitors01:25

    Antihypertensive Drugs: Direct Renin Inhibitors

    The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
    1.9K
    Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

    Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

    Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
    2.9K
    Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers01:22

    Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers

    α-Adrenergic antagonists, known as α-blockers, exert their effects by inhibiting α-adrenoceptors, leading to specific physiological actions. α1-blockers and α2-blockers have distinct pharmacological actions and therapeutic applications.
    α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally,...
    1.9K
    Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers01:17

    Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers

    Adrenergic antagonists, or sympatholytics, inhibit adrenoceptor activation driven by catecholamines or agonists. Based on their adrenoceptor specificity, adrenergic blockers can be categorized into two primary groups: α-adrenergic blockers (α-blockers) and β-adrenergic blockers (β-blockers). α-blockers interact with α1 and α2 subtypes of α-adrenoceptors.
    Nonselective α-blockers: Nonselective α-blockers contain haloalkylamine or imidazoline...
    1.9K