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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Survival Analysis01:21

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Related Experiment Video

Updated: Apr 19, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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[Screening for prostate cancer: present status and future perspectives].

Kazuto Ito

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 19, 2014
    PubMed
    Summary

    Prostate specific antigen (PSA) testing in Japan offers early prostate cancer detection but has low screening rates. Optimizing screening systems can reduce overdetection and overtreatment, enhancing benefits.

    Area of Science:

    • Urology
    • Oncology
    • Public Health

    Context:

    • Prostate specific antigen (PSA) testing is available in 90% of Japanese medical checkup institutions.
    • Screening rates for prostate cancer in Japan are significantly lower than in Western countries.

    Purpose:

    • To evaluate the benefits and drawbacks of PSA-based screening for prostate cancer in Japan.
    • To propose an optimal screening system to mitigate overdetection and overtreatment.

    Summary:

    • PSA screening can reduce prostate cancer mortality and prevent metastatic disease, as confirmed by recent trials.
    • Potential drawbacks include overdetection and overtreatment, impacting quality of life (QOL).
    • Developing a fact sheet and an optimized screening system with accurate detection and surveillance strategies is crucial.

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    Impact:

    • Implementing improved diagnostic and treatment strategies will enhance PSA screening benefits and minimize risks.
    • Current consensus supports PSA screening following Japanese Urological Association guidelines.