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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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Related Experiment Video

Updated: Apr 19, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
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[Biomarker].

Shunichi Ogawa

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 19, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Identifying reliable biomarkers is crucial for managing Kawasaki disease (KD). Pentraxin 3 (PTX3) and others show promise in predicting serious complications like coronary artery lesions (CAL) and non-responsiveness to treatment.

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    Area of Science:

    • Cardiovascular Medicine
    • Pediatric Rheumatology
    • Biomarker Discovery

    Context:

    • Kawasaki disease (KD) is a critical pediatric illness where coronary artery lesions (CAL) pose the most significant risk.
    • Incomplete KD and non-responsiveness to intravenous gamma-globulin (IVIG) therapy are associated with higher CAL incidence.
    • Accurate diagnosis and prediction of complications in KD remain challenging.

    Purpose:

    • To review and highlight the utility of specific biomarkers in diagnosing incomplete KD and predicting complications.
    • To assess the role of biomarkers in evaluating treatment response and long-term sequelae.
    • To identify potential single biomarkers for improved clinical management of KD.

    Summary:

    • Pentraxin 3 (PTX3), endothelin-1 (ET-1), brain natriuretic peptide (BNP), and N-terminal pro-brain natriuretic peptide are key biomarkers.
    • These biomarkers aid in diagnosing incomplete KD and predicting IVIG non-responsiveness and CAL formation during the acute phase.
    • Certain biomarkers also assist in evaluating chronic coronary arteritis and atherosclerosis in the convalescent phase.

    Impact:

    • Provides a consolidated overview of promising biomarkers for KD management.
    • Facilitates earlier detection and intervention for patients at high risk of CAL.
    • Supports the development of personalized treatment strategies for Kawasaki disease.