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Updated: Apr 19, 2026
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Insights
Identifying reliable biomarkers is crucial for managing Kawasaki disease (KD). Pentraxin 3 (PTX3) and others show promise in predicting serious complications like coronary artery lesions (CAL) and non-responsiveness to treatment.
Area of Science:
- Cardiovascular Medicine
- Pediatric Rheumatology
- Biomarker Discovery
Context:
- Kawasaki disease (KD) is a critical pediatric illness where coronary artery lesions (CAL) pose the most significant risk.
- Incomplete KD and non-responsiveness to intravenous gamma-globulin (IVIG) therapy are associated with higher CAL incidence.
- Accurate diagnosis and prediction of complications in KD remain challenging.
Purpose:
- To review and highlight the utility of specific biomarkers in diagnosing incomplete KD and predicting complications.
- To assess the role of biomarkers in evaluating treatment response and long-term sequelae.
- To identify potential single biomarkers for improved clinical management of KD.
Summary:
- Pentraxin 3 (PTX3), endothelin-1 (ET-1), brain natriuretic peptide (BNP), and N-terminal pro-brain natriuretic peptide are key biomarkers.
- These biomarkers aid in diagnosing incomplete KD and predicting IVIG non-responsiveness and CAL formation during the acute phase.
- Certain biomarkers also assist in evaluating chronic coronary arteritis and atherosclerosis in the convalescent phase.
Impact:
- Provides a consolidated overview of promising biomarkers for KD management.
- Facilitates earlier detection and intervention for patients at high risk of CAL.
- Supports the development of personalized treatment strategies for Kawasaki disease.
Abstract:
The most serious complication of Kawasaki disease(KD) is coronary artery lesions (CAL), which mainly occur in patients with the incomplete form of KD and intravenous gamma-globulin therapy non-responsiveness (IVIG non-responsiveness). Recently, numerous biomarkers for diagnosis of the incomplete form of KD, endothelial dysfunction, and myocardial disturbance, as well as for the prediction of CAL formation and IVIG non- responsiveness, have been reported. However, a useful single biomarker has yet to be described. Pentraxin 3 (PTX3), endothelin-1(ET-1), brain natriuretic peptide(BNP) and N-terminal pro-brain natriuretic peptide are produced and secreted from vascular and/or myocardial tissue, and are very useful for diagnosis of the incomplete form of KD, and for the prediction of IVIG non-responsiveness and CAL formation in the acute phase. Further- more, some biomarkers are helpful for evaluating chronic coronary arteritis and atheroscle- rosis in the convalescent phase of KD.
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