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Updated: Apr 19, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
[Holter monitoring data in children with gastroesophageal reflux disease]
Insights
Holter monitoring reveals cardiovascular autonomic dysfunction in children with gastroesophageal reflux disease (GERD). Findings indicate increased arrhythmias and altered heart rate variability, suggesting preclinical issues in pediatric GERD patients.
Area of Science:
- Pediatric Cardiology
- Gastroenterology
- Autonomic Nervous System Function
Background:
- Gastroesophageal reflux disease (GERD) can impact multiple organ systems.
- Cardiovascular system involvement in pediatric GERD is not fully understood.
- Autonomic dysfunction may play a role in GERD complications.
Purpose of the Study:
- To assess the cardiovascular system's functional state in children with GERD.
- To utilize Holter monitoring for detecting cardiac abnormalities in pediatric GERD.
- To correlate Holter findings with GERD and chronic gastroduodenitis.
Main Methods:
- Examined 117 school-aged children (69 GERD, 48 chronic gastroduodenitis).
- Utilized esophagogastroduodenoscopy, 24-hour pH-monitoring, ECG, and Holter monitoring.
- Analyzed frequency domain parameters and arrhythmias from Holter data.
Main Results:
- Children with GERD showed increased low-frequency components in frequency domain analysis.
- Elevated number of nocturnal premature ventricular contractions (PVCs) observed in GERD patients.
- Increased duration of enhanced dispersion periods noted in the GERD group.
Conclusions:
- Holter monitoring effectively detects preclinical ectopic rhythms in pediatric GERD.
- Frequency domain analysis aids in evaluating autonomic dysfunction in these children.
- Holter monitoring can predict nocturnal symptoms associated with GERD.
Abstract:
The aim of research is to estimate the functional state of the cardiovascular system in children with gastroesophageal reflux disease (GERD) with the help of Holter monitoring. 117 children of school age were examined: 69 children with GERD and 48 children with chronic gastroduodenitis. All children passed esophagogastroduodenoscopy, 24-hour pH-monitoring, electrocardiography and Holter monitoring. According to Holter monitoring data it was revealed that children with GERD had increased low-frequency components of frequency domain analyses, increased number of nocturnal PVCs and increased time of enhanced dispertion periods. Holter monitoring in patients with GERD can be used to detect preclinical ectopic rhythm, to evaluate autonomic dysfunction by frequency domain analyses, to predict nocturnal symptoms.
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