Related Experiment Video

Updated: Apr 19, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

69.4K

[Ulcerative colitis--difficulties of differential diagnosis in children]

É I Alieva, E A Potapova

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |December 19, 2014
    PubMed

    Insights

    Childhood chronic bowel diseases, like ulcerative colitis (UC), are frequently undiagnosed and can develop after infections. UC is often linked to primary sclerosing cholangitis (PSC) in pediatric patients.

    Area of Science:

    • Pediatric Gastroenterology
    • Hepatology
    • Immunology

    Background:

    • Chronic bowel diseases, including ulcerative colitis (UC) and Crohn's disease, are underdiagnosed in children.
    • These conditions can arise following acute intestinal infections, eating disorders, or other immunocomplex diseases.
    • Ulcerative colitis (UC) is notably associated with primary sclerosing cholangitis (PSC), affecting a significant portion of pediatric patients.

    Observation:

    • The co-occurrence of UC and PSC is more prevalent than often recognized in pediatric populations.
    • Children with combined UC and PSC represent 10.0-15.0% of admissions in specialized pediatric gastroenterology units.
    • The article details a specific case illustrating the development of UC alongside primary sclerosing cholangitis.

    Findings:

    • Childhood UC is a common precursor or co-morbidity in cases of PSC.
    • A substantial percentage of pediatric PSC cases involve concurrent UC.
    • The presented case highlights the clinical presentation of UC in the context of PSC.

    Implications:

    • Increased awareness and diagnostic vigilance for UC in children presenting with or at risk for PSC are warranted.
    • Early identification and management of pediatric UC-PSC co-morbidity can potentially improve patient outcomes.
    • Further research into the pathogenesis and optimal treatment strategies for this combined condition in children is essential.

    More Related Videos

    Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.505:45

    Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

    Published on: April 26, 2019

    14.3K
    Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis09:44

    Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

    Published on: October 14, 2025

    625

    Related Concept Videos

    Inflammatory Bowel Disease I: Ulcerative Colitis01:27

    Inflammatory Bowel Disease I: Ulcerative Colitis

    Introduction
    Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
    Risk Factors
    The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
    1.6K
    Inflammatory Bowel Disease IV: Clinical Manifestations01:20

    Inflammatory Bowel Disease IV: Clinical Manifestations

    Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
    16
    Inflammatory Bowel Disease II: Ulcerative Colitis01:20

    Inflammatory Bowel Disease II: Ulcerative Colitis

    Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
    19
    Inflammatory Bowel Disease I: Introduction01:26

    Inflammatory Bowel Disease I: Introduction

    Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
    20
    Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

    Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

    Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
    Diagnostic studies
    A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
    1.1K
    Chronic Bowel Disorders: Introduction01:17

    Chronic Bowel Disorders: Introduction

    Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
    Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
    963