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A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

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[Diagnostic of oncology diseases by the flexible biomarker]

D N Bakhmutov, I E Gudkova, L B Lazebnik

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |December 19, 2014
    PubMed

    Abstract:

    It is Known that the interest of express diagnostic oncology degasses is growing up every ear. Recently, researchers from different countries proved highly effective studies of exhaled air in the diagnosis of breast cancer, cancer of lung and gastrointestinal tract. The purpose of our study was to identify a biomarker in the air of patients using hrormato-mass-spectrometer. We examined 79 patients. 47 patients with clinically and histologically proven oncology proses (II-IV stage), and 32 patients as a control group--without cancer. Chromatograms were obtaining, which was defining from 50 to 70 individual compounds. The overwhelming majority of cancer patients present organic matter--a biomarker and absent in the healthy group. At this stage of the technical capabilities of the equipment made it possible to carry out only a qualitative determination of this biomarker.

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