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Updated: Apr 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Desquamative interstitial pneumonia: a case report.

Aleksandra Lovrenski, Živka Eri, Dragana Tegeltija

    Srpski Arhiv Za Celokupno Lekarstvo
    |December 19, 2014
    PubMed
    Summary
    This summary is machine-generated.

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    Desquamative interstitial pneumonia (DIP) is a rare lung disease. Treatment, including smoking cessation and medication, led to symptom improvement and reduced lung abnormalities in one patient.

    Area of Science:

    • Pulmonology
    • Pathology
    • Radiology

    Background:

    • Desquamative interstitial pneumonia (DIP) is an exceptionally rare idiopathic interstitial pneumonia.
    • It represents the rarest form of smoking-related interstitial lung diseases.
    • Histologically, DIP features eosinophilic macrophages filling airspaces, often with a light-brown pigment.

    Observation:

    • A 56-year-old male smoker presented with dry cough and shortness of breath.
    • Lung function tests revealed moderate restrictive disorder and severe diffusion capacity reduction.
    • Open lung biopsy confirmed the diagnosis of desquamative interstitial pneumonia.

    Findings:

    • The patient received corticosteroid and immunosuppressive therapy and quit smoking.
    • Two years post-treatment, the patient reported feeling well.

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  • High-resolution computed tomography (HRCT) demonstrated regression of pathological changes.

    • Implications:

    • While many DIP patients improve with treatment, some may progress to irreversible fibrosis.
    • Early diagnosis and intervention, including smoking cessation, are crucial for managing DIP.
    • This case highlights the potential for significant recovery in desquamative interstitial pneumonia with appropriate therapy.