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Updated: Apr 19, 2026

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging
Published on: July 28, 2020
[Topology and planar polarity of the Xenopus embryonic ciliated epithelium]
Abstract:
The effect of mechanical stress on the topology and planar polarity (PP) of the Xenopus embryonic ciliated epithelium was studied. It was found that the explantation of different sections of the blastocoel roof of the early gastrula disrupted the normal orientation of rows of ciliated cells (CCs) and led to the partition of zones with a single PP into several sections with different polarity or to the occurrence of chaotic patterns. Mechanical stretching of explants increased the order of their PP and oriented it predominantly perpendicular to the stretching axis. Changes in mechanical stress had no significant effect on the ciliated epithelium topology.
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