Hematology references for three laboratory mice strains

Area of Science:

• Veterinary Medicine
• Toxicology
• Laboratory Animal Science

Background:

• Standardized reference data for hematologic indicators in common laboratory mouse strains are crucial for preclinical research.
• Balb/c, C57BL/6, and CD1 mice are widely utilized in drug development and toxicological studies.
• Variations in hematologic parameters can impact the interpretation of toxicity study results.

Purpose of the Study:

• To establish comprehensive reference ranges for key hematologic indicators in three commonly used mouse strains.
• To provide essential baseline data for investigators performing preclinical toxicity assessments.
• To facilitate more accurate and reliable interpretation of toxicological findings in Balb/c, C57BL/6, and CD1 mice.

Main Methods:

• Hematologic parameters were measured in Balb/c, C57BL/6, and CD1 mice.
• Animals were standardized by sex (1:1 ratio) and age.
• Data collection was performed under standard laboratory conditions.

Main Results:

• Mean and standard deviation values for main hematologic indicators were determined for each mouse strain.
• Reference data were compiled for male and female mice of varying ages.
• The collected data provide a baseline for normal hematologic values in these strains.

Conclusions:

• The generated reference data are valuable for researchers conducting preclinical toxicity studies.
• These hematologic profiles aid in the qualitative and quantitative assessment of toxicity in Balb/c, C57BL/6, and CD1 mice.
• The study enhances the reliability of toxicological evaluations using these widely adopted mouse models.