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A unique MRI presentation of fungal infection in the brain

Muhammad Bilal Salman Khan1, Saad Shafqat2, Syed Ather Enam3

  • 1Department of Internal Medicine, Good Samaritan Hospital, Cincinnati, OH, USA.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|December 19, 2014
PubMed

Insights

Fungal infections of the central nervous system (CNS) can present unusual MRI findings. This case report emphasizes considering fungal infections in immunocompetent hosts, even with atypical imaging characteristics.

Area of Science:

  • Neurology
  • Radiology
  • Mycology

Background:

  • Central nervous system (CNS) fungal infections are geographically prevalent.
  • Magnetic resonance imaging (MRI) is crucial for prediagnosis but can yield misleading results.
  • Distinguishing fungal infections from other CNS lesions can be challenging.

Observation:

  • This case report details unusual MRI findings in an immunocompetent host with CNS fungal infection.
  • The MRI exhibited hyper-intense signals on T2-weighted images and patchy post-contrast enhancement.
  • Associated surrounding edema was also noted on the MRI scans.

Findings:

  • The observed MRI characteristics mimicked a neoplastic lesion.
  • Histopathology confirmed the diagnosis as aspergillosis.
  • This highlights atypical imaging presentations of fungal CNS infections.

Implications:

  • Unusual MRI findings necessitate considering fungal infections in the differential diagnosis of CNS mass lesions.
  • Radiologists and clinicians should be aware of atypical presentations of fungal CNS infections.
  • Early and accurate diagnosis is crucial for effective management of CNS fungal infections.

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