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Related Concept Videos

Ascites01:19

Ascites

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DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...
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Cholecystitis01:20

Cholecystitis

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Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
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Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
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Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Related Experiment Video

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Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
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An infant with biliary ascites.

Anjum Saeed1, Mohammed El Mouzan2, Asaad Assiri1

  • 1Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Khalid University Hospital, King Saud University, Riyadh, KSA.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|December 19, 2014
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Summary

Biliary ascites in children, a rare condition from bile duct perforation, presents insidiously with jaundice and abdominal distension. This case report details an infant

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Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Surgical Pediatrics

Background:

  • Biliary ascites in children is rare, with unknown exact pathogenesis.
  • Proposed mechanisms include congenital ductal weakness, pancreaticobiliary malunion, tuberculosis, necrotizing enterocolitis, and choledochal cyst rupture.

Observation:

  • Presents acutely or sub-acutely, often insidiously in children.
  • Common symptoms include jaundice, clay-colored stools, abdominal distension, elevated liver enzymes, and cholestasis.

Findings:

  • Diagnosis aided by clinical suspicion, ultrasound, CT, MRCP, and ascitic fluid analysis.
  • This report details a 7-month-old infant with biliary ascites due to bile duct perforation.

Implications:

  • Highlights the importance of considering bile duct perforation in pediatric biliary ascites.
  • Management involves both conservative and surgical approaches.
  • Contributes to understanding rare pediatric hepatobiliary emergencies.