Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
Mitochondria01:37

Mitochondria

21.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.7K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.9K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.9K
Evolutionary Processes in Microbes01:26

Evolutionary Processes in Microbes

189
Microbial evolution occurs rapidly due to short generation times and a variety of genetic processes, including horizontal gene transfer, mutation, recombination, and genetic drift. These mechanisms collectively enable microbes to adapt swiftly to changing environments.Horizontal gene transfer (HGT) allows genes to move between different species and occurs through three main mechanisms: conjugation, transformation, and transduction. Conjugation involves direct cell-to-cell contact for DNA...
189
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

472
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
472
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.3K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mammal Aging as a Programmed Life Cycle Function - Resolving the Cause and Effect Conundrum.

Advanced biology·2024
Same author

Mammal Aging is Controlled by an Evolvability-Based Adaptive Program.

Biochemistry. Biokhimiia·2023
Same author

Evolution of Aging Theories: Why Modern Programmed Aging Concepts Are Transforming Medical Research.

Biochemistry. Biokhimiia·2017
Same author

Emerging programmed aging mechanisms and their medical implications.

Medical hypotheses·2015
Same author

Solving the programmed/non-programmed aging conundrum.

Current aging science·2015
Same author

Is the evolutionary programmed/ non-programmed aging argument moot?

Current aging science·2015

Related Experiment Video

Updated: Apr 19, 2026

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.8K

Modern evolutionary mechanics theories and resolving the programmed/non-programmed aging controversy.

Theodore C Goldsmith1

  • 1Azinet LLC, Box 239, Crownsville, MD, 21032, USA. tgoldsmith@azinet.com.

Biochemistry. Biokhimiia
|December 19, 2014
PubMed
Summary

Programmed aging theories suggest mammals evolved lifespan limits for evolutionary benefit, challenging older views. This research indicates programmed aging now has stronger evolutionary support than non-programmed theories, impacting medical research on aging.

More Related Videos

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

4.5K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.9K

Related Experiment Videos

Last Updated: Apr 19, 2026

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.8K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

4.5K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.9K

Area of Science:

  • Evolutionary biology
  • Gerontology
  • Mammalian lifespan determination

Background:

  • Historically, programmed aging theories for mammals were rejected due to perceived evolutionary incompatibility.
  • Non-programmed theories attribute aging to natural deterioration, with species lifespan differences explained by resistance to these processes.

Purpose of the Study:

  • To re-evaluate the evolutionary basis of programmed aging theories in mammals.
  • To determine the current scientific standing of programmed versus non-programmed aging theories.
  • To highlight the implications of aging theories for understanding age-related diseases.

Main Methods:

  • Review of recent evolutionary and biological developments.
  • Comparative analysis of programmed and non-programmed aging frameworks.
  • Assessment of evolutionary support for competing aging theories.

Main Results:

  • Recent scientific advancements have significantly strengthened the evolutionary basis for programmed aging in mammals.
  • Programmed aging theories now possess more robust evolutionary support compared to non-programmed theories.
  • The distinction between programmed and non-programmed aging has critical implications for medical research.

Conclusions:

  • Programmed aging in mammals is now evolutionarily more plausible than previously assumed.
  • The resolution of the programmed aging debate is crucial for directing future medical research into age-related conditions.
  • Understanding the evolutionary drivers of aging is key to addressing diseases associated with senescence.