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Comparison of stool colonization in premature infants by three dose regimes of a probiotic combination: a randomized

Sourabh Dutta1, Pallab Ray2, Anil Narang1

  • 1Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

American Journal of Perinatology
|December 19, 2014
PubMed

Insights

High-dose and standard-dose probiotics achieved similar stool colonization in premature infants. Both probiotic regimens effectively colonized infants compared to placebo, with no significant differences between the doses tested.

Area of Science:

  • Neonatal Medicine
  • Microbiology
  • Clinical Trials

Background:

  • Premature infants are vulnerable to gut dysbiosis.
  • Probiotics are explored to improve gut health in neonates.

Purpose of the Study:

  • To compare stool colonization rates in premature infants receiving high-dose versus standard-dose probiotics.

Main Methods:

  • Blinded, randomized, placebo-controlled trial in a Level III neonatal unit.
  • 149 infants (gestational age 27-33 weeks) received varying probiotic doses or placebo for 14-21 days.
  • Stool colonization by probiotic organisms was assessed at 28 days.

Main Results:

  • Significant colonization with Lactobacillus and Bifidobacterium in all probiotic groups compared to placebo.
  • No significant difference in colonization rates between high-dose and standard-dose probiotic groups.
  • Trends suggested higher colony-forming units with higher doses, but this was not statistically significant.

Conclusions:

  • Proportion of infants colonized was similar across different probiotic dosing strategies.
  • Both high-dose and standard-dose probiotic regimens are effective for gut colonization in premature infants.
Abstract

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