Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

91.6K
Overview
91.6K
Fault Types01:18

Fault Types

549
When analyzing a single line-to-ground fault from phase A to ground at a three-phase bus, it is important to consider the fault impedance. This impedance is zero for a bolted fault, equal to the arc impedance for an arcing fault, and represents the total fault impedance for a transmission-line insulator flashover. To derive sequence and phase currents, fault conditions are translated from the phase domain to the sequence domain.
For line-to-line faults occurring between phases B and C, the...
549
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

415
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
415
Heuristics01:21

Heuristics

922
Heuristics are problem-solving strategies that use mental shortcuts to simplify decision-making. Unlike algorithms, which must be followed precisely to achieve a correct result, heuristics offer a general problem-solving framework. They save time and energy but can sometimes lead to less rational decisions.
People often rely on heuristics when faced with an overload of information, limited time, low importance of the decision, limited information, or when a heuristic readily comes to mind. For...
922
Phylogenetic Trees03:21

Phylogenetic Trees

52.3K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
52.3K
Probability Laws01:49

Probability Laws

45.4K
Overview
45.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The RNA-binding protein HuR modulates the expression of the disease-linked <i>CCL2</i> rs1024611G-rs13900T haplotype.

eLife·2026
Same author

Early-Life Exposure to Organic Chemical Pollutants as Assessed in Primary Teeth and Cardiometabolic Risk in Mexican American Children: A Pilot Study.

International journal of environmental research and public health·2025
Same author

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.

medRxiv : the preprint server for health sciences·2025
Same author

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.

Nature communications·2025
Same author

Evaluating Nanopore Sequencing as a Respiratory Virus Diagnostic Tool for the Prehospital Setting.

Military medicine·2025
Same author

A Baseline Model of PTSD From the ACES Cohort.

Military medicine·2024

Related Experiment Video

Updated: Apr 19, 2026

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
11:54

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

9.9K

Imputation in families using a heuristic phasing approach.

August N Blackburn1, Angela K Dean2, Donna M Lehman2

  • 1Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7702 Floyd Curl Road, San Antonio, TX 78229, USA.

BMC Proceedings
|December 19, 2014
PubMed
Summary

A new imputation method allows whole genome sequencing data to be inferred in large, complex family structures. This advances genetic analysis for distantly related individuals, overcoming previous computational and relationship limitations.

More Related Videos

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.7K
Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening
14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

5.1K

Related Experiment Videos

Last Updated: Apr 19, 2026

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
11:54

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

9.9K
Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.7K
Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening
14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

5.1K

Area of Science:

  • Genetics
  • Bioinformatics
  • Computational Biology

Background:

  • Whole genome sequencing (WGS) provides comprehensive genetic data but is costly.
  • Existing imputation methods struggle with large pedigrees and distant relationships.
  • Genome-wide association studies (GWAS) utilize genotyped single nucleotide polymorphisms (SNPs).

Purpose of the Study:

  • To develop an advanced imputation method for WGS data in complex, multigenerational pedigrees.
  • To overcome limitations of current imputation techniques regarding pedigree size, relationship distance, and computational efficiency.
  • To enable accurate genotype imputation across distantly related individuals.

Main Methods:

  • Developed a novel imputation framework leveraging identity by descent (IBD) for arbitrarily shaped pedigrees.
  • Applied the method to genotype-by-genotype imputation using single nucleotide polymorphism (SNP) data from genome-wide association studies (GWAS).
  • Validated the approach using WGS data from the Genetic Analysis Workshop 18 (GAW18).

Main Results:

  • The new method successfully imputes genotypes in large and complex multigenerational pedigrees.
  • It accurately imputes genotypes across distantly related individuals based on identity by descent.
  • The approach demonstrates computational feasibility for large-scale genetic analyses.

Conclusions:

  • This method significantly enhances the ability to impute whole genome sequencing data in related individuals.
  • It overcomes major limitations of existing imputation techniques, particularly for complex family structures.
  • The approach holds promise for advancing genetic research by making WGS data more accessible and interpretable in diverse populations.