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Metal complexes of antiinflammatory drugs. Part VII: Salsalate complex of copper(II)
A E Underhill1, A Bury, R J Odling
1Department of Chemistry, University College of North Wales, Bangor, United Kingdom.
Journal of Inorganic Biochemistry
|September 1, 1989
Abstract:
The preparation and properties of the Cu(II) complex Cu(SAS)2.H2O are reported for the antiinflammatory drug Salsalate (SAS). The diffuse reflectance spectra and magnetic moments are consistent with a dinuclear structure as found for [Cu(aspirinate)2(H2O)]2. The Cu(II) complex exhibits an increased superoxide dismutase activity compared with the parent drug molecule in the nitroblue tetrazolium assay.