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Oral glucose in preterm neonates during oropharyngeal suctioning: a randomized controlled cross-over trial

Katharina Vezyroglou1, Katrin Mehler, Angela Kribs

  • 1Department of Neonatology and Pediatric Intensive Care Medicine, Children's Hospital, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany, katharina.vezyroglou@uk-koeln.de.

European Journal of Pediatrics
|December 19, 2014
PubMed

Insights

Oral glucose did not significantly reduce pain in preterm infants during oropharyngeal suctioning. This study found no significant benefit of glucose for pain relief in neonates undergoing the procedure.

Area of Science:

  • Neonatal care
  • Pain management in infants
  • Pediatric anesthesiology

Background:

  • Oropharyngeal suctioning is a common procedure in preterm infants.
  • Pain and stress responses during neonatal procedures require effective management strategies.
  • Oral glucose is a potential non-pharmacological analgesic for neonates.

Purpose of the Study:

  • To determine if oral glucose administration reduces pain response in preterm infants during oropharyngeal suctioning.
  • To evaluate the efficacy of glucose as an analgesic in this vulnerable population.
  • To assess the safety of oral glucose administration during nasal CPAP.

Main Methods:

  • Randomized, double-blind, placebo-controlled cross-over trial.
  • Inclusion of 32 preterm infants with birth weight >1500 g on nasal CPAP.
  • Assessment of pain using the Premature Infant Pain Profile (PIPP) score.

Main Results:

  • Mean PIPP score after placebo was 8.6 (95% CI 7.8-9.4).
  • Mean PIPP score after glucose administration was 8.0 (95% CI 7.1-8.9).
  • No statistically significant difference in PIPP scores between glucose and placebo (p=0.23).

Conclusions:

  • Oral glucose administration did not provide significant analgesia during oropharyngeal suctioning in late preterm infants.
  • No serious adverse events were observed during oral glucose administration under nasal CPAP.
  • Further research may be needed to explore alternative pain management strategies for neonates.
Abstract

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