Long-range GABAergic neurons in the prefrontal cortex modulate behavior
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Updated: Apr 19, 2026

Whole-cell Currents Induced by Puff Application of GABA in Brain Slices
Published on: October 12, 2017
Christian Bravo-Rivera1, Maria M Diehl1, Ciorana Roman-Ortiz1
1Department of Psychiatry and Department of Anatomy & Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Abstract:
Cortical glutamatergic projections are extensively studied in behavioral neuroscience, whereas cortical GABAergic projections to downstream structures have been overlooked. A recent study by Lee and colleagues (Lee AT, Vogt D, Rubenstein JL, Sohal VS. J Neurosci 34: 11519-11525, 2014) used optogenetic and electrophysiological techniques to characterize a behavioral role for long-projecting GABAergic neurons in the medial prefrontal cortex. In this Neuro Forum, we discuss the potential implications of this study in several learning and memory models.
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