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Updated: Apr 19, 2026
A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
Published on: April 18, 2025
Mass spectrometry-based proteomics in Chest Medicine, Gerontology, and Nephrology: subgroups omics for personalized
Shih-Yi Lin1, Wu-Huei Hsu2, Cheng-Chieh Lin3
1Institute of Clinical Medical Science, China Medical University College of Medicine, 404 Taichung, Taiwan ; Department of Internal Medicine, China Medical University Hospital, 404 Taichung, Taiwan ; Division of Nephrology and Kidney Institute, China Medical University Hospital, 404 Taichung, Taiwan.
Abstract:
Mass spectrometry (MS) is currently the most promising tool for studying proteomics to investigate largescale proteins in a specific proteome. Emerging MS-based proteomics is widely applied to decipher complex proteome for discovering potential biomarkers. Given its growing usage in clinical medicine for biomarker discovery to predict, diagnose and confer prognosis, MS-based proteomics can benefit study of personalized medicine. In this review we introduce some fundamental MS theory and MS-based quantitative proteomic approaches as well as several representative clinical MS-based proteomics issues in Chest Medicine, Gerontology, and Nephrology.
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