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Optimization of Crystal Growth for Neutron Macromolecular Crystallography
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Controlling pharmaceutical crystallization with designed polymeric heteronuclei.

Laura Y Pfund1, Christopher P Price, Jessica J Frick

  • 1Department of Chemistry and the Macromolecular Science and Engineering Program, The University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.

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Summary
This summary is machine-generated.

Researchers transformed crystallization inhibitors into promoters by incorporating them into polymers. This innovation significantly speeds up crystal formation, aiding compounds resistant to crystallization and improving solid form discovery.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Crystallization Science

Background:

  • Crystallization inhibitors can hinder desired crystal formation.
  • Developing methods to control crystallization kinetics is crucial for pharmaceutical development and materials science.
  • Tailoring molecular additives offers a potential route to manipulate crystallization processes.

Purpose of the Study:

  • To investigate if molecules that inhibit crystallization in solution can be modified to promote it.
  • To synthesize novel polymerizable additives mimicking acetaminophen and mefenamic acid.
  • To explore the effect of incorporating these additives into polymers on crystallization induction time.

Main Methods:

  • Synthesis of polymerizable additives designed to mimic pharmaceutical structures.
  • Evaluation of additive performance in solution, observing face-selective inhibition and crystal growth.
  • Incorporation of additives into an insoluble polymer matrix.
  • Measurement of crystallization induction time for pharmaceuticals in the presence of polymer-bound additives.

Main Results:

  • Additives synthesized showed face-selective inhibition of crystal growth in solution, slowing crystal appearance.
  • Incorporation of these additives into an insoluble polymer substantially decreased the induction time for crystal formation of acetaminophen and mefenamic acid.
  • The polymer-bound additives acted as crystallization promoters, contrasting their solution behavior.

Conclusions:

  • Tailor-made polymers can be synthesized to transform crystallization inhibitors into promoters.
  • This approach effectively reduces the induction time for crystal appearance.
  • The method holds potential for compounds resistant to crystallization and for enhancing heteronucleation in solid form discovery.